Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

by Nathalia Holt
Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

by Nathalia Holt

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Overview

“Nathalia Holt presents a thorough account of the research that provides scientists with hope that a cure will one day be achievable... and her empathy shines through in her prose. This is as important a social history as it is a medical document.”—The Daily Beast
 
Two patients—each known in medical history as the Berlin Patient—were cured of the HIV virus. The two patients’ disparate cures came twelve years apart, but Nathalia Holt, an award-winning scientist at the forefront of HIV research, connects the molecular dots of these cases for the first time.
 
Scientists are known to maintain a professional distance from those they study, but sometimes scientists are not just investigators, they are caregivers, too. Cured illustrates that even in the era of high-tech and big pharma, the way doctors and patients communicate remains a critical ingredient in the advance of this science. Holt offers a kind of hope that the thirty-four million people currently infected with HIV need and a story of ingenuity, dedication, and humanity that will inspire the rest of us.

Product Details

ISBN-13: 9780698148543
Publisher: Penguin Publishing Group
Publication date: 02/27/2014
Sold by: Penguin Group
Format: eBook
Pages: 336
File size: 2 MB
Age Range: 18 Years

About the Author

Nathalia Holt trained at Massachusetts General Hospital, MIT, Harvard University, the University of Southern California, and Tulane University. She lives with her family in Boston.

Table of Contents

Cast of Characters xi

Preface xiii

Part I A Doctor, Two Patients, and Some Tests

Chapter 1 The Good Doctor in Denial 3

Chapter 2 A Visit with the Family Doctor 13

Chapter 3 Death Sentence? 21

Part II The Disease, a Drug, and Its Industry

Chapter 4 Viral Trojan Horse 33

Chapter 5 A Weapon from the War on Cancer 43

Chapter 6 The Days of Acting Up 57

Chapter 7 Recognizing a Global Pandemic 65

Chapter 8 From the One Percent 79

Chapter 9 But, Doctor, I Don't Feel Sick 87

Chapter 10 The Delta 32 Mutation 95

Chapter 11 Calling All Elite Controllers 99

Chapter 12 Treatment in Hiding 111

Part III Treating the Berlin Patients

Chapter 13 The Second Diagnosis 119

Chapter 14 The Compassionate Use Exemption 131

Chapter 15 Three Deadly Diseases Move In 135

Chapter 16 The Comfort of Family and Strangers 141

Chapter 17 Timing 147

Chapter 18 Transplanting 153

Chapter 19 "Perhaps We Have Eradicated HIV" 163

Chapter 20 An Unexciting Recovery 175

Part IV The Cure

Chapter 21 Trials 185

Chapter 22 Proof of Principle 199

Chapter 23 The Good Doctor in Court 205

Chapter 24 Not Even Surprising 209

Chapter 25 The Promise Kept 221

Chapter 26 A Child Cured-So What? 241

Chapter 27 Zinc Finger Snap 249

Chapter 28 The Abused, the Respected, the Relentless 261

Notes 273

Timeline 297

Acknowledgments 299

Index 303

What People are Saying About This

From the Publisher

“I am eagerly anticipating Nathalia Holt’s telling of the Berlin Patients and the implications of their apparent cure from HIV infection.”
—David Baltimore, Nobel Laureate for Medicine, professor of Biology, and former president, California Institute of Technology

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